What's Behind the Door?

When a friend approached me with a lead on a permanent position I nearly leapt from my feet and hugged her.  I've been working under a temporary contract for two years and it now looks as if the job maybe outsourced to another country sometime in the next few months. In view of this, this opportunity for a regular job seemed perfect - until I dug into the job description.

Yes, it is within my experience and skill set. Yes, I am a good candidate. What I read that has me not so thrilled were the words: may need to work holidays. I have seen this before, and it usually means shift work. I've tried working nights when I was younger. It was a disaster for both my employer and myself, and yet in this economy, and at my age, can I turn down the chance of employment with full benefits?